NFL GameDay 2000 is a simulation sports game in which players can control football teams and execute plays to compete against AI or other players. In this game, players experience a realistic depiction of American football, with detailed gameplay mechanics that include strategic play-calling, player movements, and game management, set within the context of the NFL season. It stands out with its enhanced AI that pre-emptively adjusts to player strategies, a wide array of motion-captured animations for more lifelike player movements, and a balanced gameplay system that emphasizes both offensive and defensive tactics, providing an immersive football simulation experience.