Plaguetrix is a single-player simulation game in which players navigate through a real video recorded alley, avoiding the plague by moving forward and sideways with time dynamics affecting gameplay. In this game, the setting is a real alley in the north east of England during a plague outbreak, creating an immersive and tense environment as players attempt to survive the infection. It stands out with its FMV (full-motion video) experiment format, where real footage is used to create a realistic experience, and unique gameplay mechanics that involve strategic movement to anticipate and evade the advancing plague.