NCAA Football 2001 is a single-player sports simulation game in which players take on the role of a college football coach, managing team strategies, calling plays, and controlling player movements during matches. In this game, the setting revolves around college football, capturing the vibrant atmosphere of game days with crowd chants, mascot antics, and team rivalries, culminating in the chance to compete in the Orange Bowl. It stands out with its detailed gameplay mechanics, including an improved running game, advanced defensive logic, and customizable team features such as logos, uniforms, and player names, offering a realistic and immersive college football experience.